The use of mechanical dyssynchrony for predicting response to cardiac resynchronization therapy in patients with non-ischemic cardiomyopathy

Abstract Funding Acknowledgements Type of funding sources: None. Aim/Introduction: Assessment mechanical dyssynchrony by myocardial perfusion gated-SPECT in patients with non-ischemic cardiomyopathy for predict response to cardiac resynchronization therapy (CRT). Materials and Methods We examined 32 before six months after CRT. Left ventricular contractility were assessed all gated-SPECT. The phase standard deviation (PSD), histogram bandwidth (HBW), skewness (S) kurtosis (K) used as an indicator the both ventricles. Results Mechanical ventricles CRT was increased patients. Median value PSD 53°(41-61°), HBW 176°(136-202°), S 1,62(1,21-1,89), K 2,81(1,21-3,49). Six 22(68%) respondents identified. divided into two groups (responders non-responders) compared parameters. It found that (44°(35-54°)) (158°(118-179°) responders significantly lower than non-responders (PSD (68°(58-72°); (205°(199-249°)). higher (Responders: 1,77(1,62-2,02); 3,03(2,60-3,58). Non-responders: 1,21(0,93-1,31); 1,21(0,19-1,46)). four indicators can according results univariate logistic regression analysis. Moreover, only (OR = 1.196, 95% CI 1.04-1.37) is independent predictor multivariate regression. Conclusion Radionuclide assessment may be optimal diagnostic method selecting on